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Klinique Active Lotion is a combination of two medicines: Cetrimide and Ketoconazole which treat dandruff. Cetrimide is an antiseptic which kills bacteria, fungi and viruses on the scalp, and treats flaky and itchy scalp. Ketoconazole is an antifungal. It works by stopping the growth of dandruff-causing fungi by preventing them from forming their own protective covering.