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Fucidin H Cream is a combination of two medicines: Fusidic Acid Topical and Hydrocortisone Topical which treat skin infections. Fusidic Acid Topical is an antibiotic which kills bacteria by preventing the synthesis of essential proteins required by bacteria to carry out vital functions. Hydrocortisone Topical is a steroid medicine. It blocks the production of certain chemical messengers (prostaglandins) that make the skin red, swollen and itchy.