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Desowen Lotion containing the active ingredient desonide is considered a topical corticosteroid type of medication. The lotion works by activating certain natural substances in the body to reduce itching, redness and swelling of the skin. The medication can be used to treat a variety of skin conditions such as allergic reactions, psoriasis and eczema. It can be used to treat the conditions but cannot be used to cure the skin conditions.